Studies Suggest That Pomegranate May Fight Certain Cancers

If an apple a day doesn’t keep the doctor away, its look-alike cousin the pomegranate just might. A study has found that a substance in pomegranates can slow or even stop the growth of breast cancer tumors. The study, just published in Cancer Prevention Research, found 10 phytochemicals in pomegranates that seem to inhibit the growth of estrogen-responsive breast tumors. (1) The phytochemicals, called ellagitannins, work by blocking an enzyme called aromatase, which feeds estrogen and plays a key role in breast tumor growth. The ellagitannin called urolithin B had the strongest inhibitory effect.

Different fruits have different mixes of ellagitannins, with each mix providing a different emphasis on benefits. Whereas the mix of ellagitannins in red raspberries appears particularly well suited in combating colon cancer, it now appears that pomegranates provide special benefits when dealing with breast cancer. The study also confirms what I’ve been saying for years about ellagic acid—that the health benefits in pomegranates and raspberries are in the ellagitannins, not the ellagic acid as offered by some supplement manufacturers.

Many of the key drugs given to patients who have estrogen-dependent breast tumors act in a fashion similar to the ellagitannins, also inhibiting aromatase. But the director of the study, Dr. Shiuan Chen of the City of Hope Cancer Research and Treatment Center in Duarte, California, said patients should not try to substitute pomegranate for their medications. “We do not recommend people start taking this as a replacement for the AI’s [aromatase inhibitors],” Dr. Chen said. “They [pomegranate compounds] are not as potent as the real drugs so we think that the interest probably is more on the prevention end rather than in a therapeutic purpose.”

Other experts also caution against relying on pomegranate as a substitute for drugs. According to Gary Stoner of Ohio State University, “It’s not clear that these levels could be achieved in animals or in humans because the (compounds) are not well absorbed into the blood when provided in the diet.”

Researchers Surprised By Results

Research suggests that pomegranates have cancer-fighting properties, specifically breast cancer

The researchers didn’t expect to find the pomegranate derivatives to be as effective as they were. “We were surprised by our findings,” Dr. Chen said. “We previously found other fruits, such as grapes, to be capable of the inhibition of aromatase. But phytochemicals in pomegranates and in grapes are different.”

The surprising factor here is that the researchers found their results surprising. After all, back in 2004, I wrote about the cancer-fighting properties of pomegranates, specifically mentioning breast cancer. On August 30, 2004, I wrote, “Supplementation with pomegranate extract makes sense if you are looking at cancer prevention, maintaining a healthy heart, reducing bad cholesterol, lowering blood pressure, and protecting against free radicals and aging.” That same year, The European Journal of Cancer Prevention published a study discussing the breast cancer-fighting properties of pomegranate juice and pomegranate oil when administered to mice. (2)

Pomegranates May Regulate Estrogen and Heart Health

Wellness and healthy eating tips suggest pomegranates may regulate estrogen and promote heart health

The fact is, supplementing with antioxidant-rich pomegranate couldn’t hurt, at worst. Scientists think the compounds in pomegranates may play a role in regulating estrogen levels and regulating menstrual and menopausal symptoms. This means that pomegranate might help reduce cramping, mood swings, hot flashes, and so on. There are plenty of other benefits associated with the fruit as well.

For one thing, research shows that pomegranate reduced heart disease risk factors not only in lab tests but also in preliminary human trials. A 2004 study published in the Journal of Clinical Nutrition found that by taking the equivalent of a cup of pomegranate juice daily for one year, patients who had severe carotid artery stenosis reduced arterial plaque by 35 percent, reduced bad cholesterol by 20 percent, reduced cholesterol oxidation by 90 percent, and reduced blood pressure in just two weeks. (3)

One year later, a study published in the American Journal of the College of Cardiology found that in just three months, drinking a cup of pomegranate juice daily improved the amount of oxygen getting to the heart muscle of patients who had heart disease. (4) All in all, it makes you wonder what Gary Stoner was referring to when he said, “[These compounds] are not well absorbed into the blood when provided in the diet.”

Pomegranates For Prostate Cancer

Wellness tips to eat antibacterial and antiviral pomegranates to combat prostate cancer

As for the cancer-fighting properties of pomegranates, several studies have found pomegranate useful in combating prostate cancer. Research out of Stanford University completed this past August found that men with prostate cancer who drank a glass of pomegranate juice daily had far slower cancer cell proliferation than those who didn’t drink the juice. (5) The researchers followed 48 men over a five-year period, and those who drank the juice took four times as long for their PSA test markers to double compared to the non-juice drinkers. Studies also have found that pomegranate juice may prevent skin and lung cancer.

Other conditions that show improvement after consuming pomegranate include erectile dysfunction, arthritis, dental plaque, and diarrhea. Plus, pomegranate juice is antibacterial and antiviral.

To enjoy pomegranate’s benefits, you can drink pomegranate juice (but make sure it isn’t sweetened, and raw chilled juice is best—not so much pasteurized), take pomegranate extract supplements, crack the fruit open and eat it, or take it as part of a superfood formula.

Material originally published at Copyright © 1999-2018. Baseline of Health® Foundation Used by permission of the Baseline of Health® Foundation. All rights reserved worldwide.
Jon Barron Health Expert

Jon Barron is the founder of the Baseline of Health® Foundation, whose website attracts millions of visitors worldwide so people can learn about health and nutrition for free. He has lectured internationally and has been featured on many regional and syndicated media programs as an expert in disease prevention, anti-aging, and nutrition.

  1. Lynn S. Adams, Yanjun Zhang, et al. “Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro.” Cancer Prev Res January 2010 3; 108.
  2. Mehta R, Lansky E. “Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture.” European Journal of Cancer Prevention: August 2004 – Volume 13 – Issue 4 – pp 345-348.
  3. Michael Aviram. Mira Rosenblat, Diana Gaitini, et al. “Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure, and LDL oxidation.” Clinical Nutrition. June 2004 Volume 23, Issue 3, Pages 423–433.
  4. Sumner MD, Elliott-Eller M, Weidner G, et al. “Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease.” Am J Cardiol. 2005 Sep 15;96(6):810-4.
  5. Allan J. Pantuck1, John T. Leppert1, et al. “Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer.” Clin Cancer Res  July 1, 2006, 12; 4018.

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